How N-SED works*

N-SED by Bosmora has multiple ingredients formulated to complement each other in supporting a healthy inflammation response. The approach utilized ingredients that are well-tolerated in amounts that studies have suggested a capacity to effect change in various inflammation cascades. For example, the study below mentions the ability of B. serrata to inhibit 5-LOX (5-lipoxygenase) from transforming essential fatty acids into inflammatory molecules called leukotrienes. Similarly, the studies below suggest the capacities of curcumin, harpagophytum, and white willow bark to interrupt the inflammation cascades of cytokines (TNFa, interleukins), and act as COX-1 and COX-2 inhibitors preventing the conversion of arachidonic acid into prostaglandin, a molecule that can promote inflammation. Bromelain has displayed fibrinolytic activity, and fibrin is associated with joint inflammation. Additionally, moringa has demonstrated anti-inflammatory effects. Piperine has shown an ability to greatly increase the absorption of curcuminoids by curbing the liver from immediately metabolizing them. These ingredients in combination create a broad spectrum to support a healthy inflammation response to help you feel good again.

Boswellia serrata "...the anti-inflammatory actions of Boswellia are credited to the tetra- and pentacyclic terpenoids called boswellic acids including β-boswellic acid and the triterpene acids acetyl-β-boswellic acid, 11-keto-β-boswellic acid, and acetyl-11-keto-β-boswellic acid (also known as tircuallic, lupeolic, and roburic acids). Out of these four boswellic acids, acetyl-11-keto-β-boswellic acid (AKBA) is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation...Boswellia acts by many of the same mechanisms as pharmaceutical nonsteroidal anti-inflammatory drugs...Much of the early research on the mechanism of action of Boswellia focused on leukotriene suppression accomplished via lipoxygenase inhibition. Numerous other anti-inflammatory mechanisms have been identified, including effects on prostaglandins, interleukins, tumor necrosis factor, and nuclear factor-κB (NF-κB), among others."

https://restorativemedicine.org/library/monographs/frankincense/

Bromelain - "In vitro and in vivo studies demonstrate that bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain is considerably absorbable in the body without losing its proteolytic activity and without producing any major side effects...It also relieves osteoarthritis, diarrhea, and various cardiovascular disorders."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529416/

"Curcumin has the ability to suppress the acute and chronic inflammation. It reduces inflammation by lowering histamine levels and by possibly increasing the production of natural cortisone by adrenal glands...The mechanism of action by which curcumin shows anti-inflammatory effect is by attenuating inflammatory response of TNF-α stimulated human endothelial cells by interfering with NF-κB."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625352/

Harpagophytum (Devils Claw) - " The Hp [Harpagophytum procumbens] extract dose-dependently inhibited the release of TNFα as well as that of interleukin (IL)-6, IL-1β and prostaglandin E₂ (PGE₂). The Hp prevented TNFα and IL-6 mRNA expression in human monocytes and cyclooxygenase-2 (COX-2)

https://pubmed.ncbi.nlm.nih.gov/22072539/

Moringa - "Extract of leaves, seeds, and bark showed significant analgesic activity in both central (hot plate method) and peripheral models (acetic acid–induced writhing method) in a dose-dependent manner, and extracts of leaves exhibited analgesic potency similar to that of indomethacin [a non-steroidal anti-inflammatory drug]..."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266645/

Piperine - "...the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers. When curcumin was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were achieved over a period of 4 h. Concomitant administration of piperine 20 mg/kg increased the serum concentration of curcumin for a short period of 1-2h post drug. Time to maximum was significantly increased (P<0.02) while elimination half life and clearance significantly decreased (P<0.02), and the bioavailability was increased by 154%. On the other hand in humans after a dose of 2g curcumin alone, serum levels were either undetectable or very low. Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1h post drug (P<0.01 at 0.25 and 0.5h; P < 0.001 at 1 h), the increase in bioavailability was 2000%."

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2006-957450

White Willow Bark - "It appears to inhibit the cyclooxygenase-2 pathway. Other components of willow bark may have other antiinflammatory properties."

https://www.sciencedirect.com/topics/neuroscience/salicin

*These published studies have not been verified by the FDA.